Page last updated: 2024-12-09

1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylic acid ethyl ester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

You're asking about a rather specific compound, **1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylic acid ethyl ester**. Let's break down its structure and potential importance in research.

**Structure and Properties:**

* **1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylic acid ethyl ester:** This is a complex organic molecule with a fused ring system. Let's break it down piece by piece:
* **Thieno[2,3-c]isoquinoline:** This is a bicyclic system where a thiophene ring (sulfur-containing ring) is fused to an isoquinoline ring (nitrogen-containing ring).
* **6,7,8,9-tetrahydro:** This indicates that the isoquinoline ring has four hydrogen atoms attached to the carbon atoms at positions 6, 7, 8, and 9, meaning it's not fully aromatic.
* **1-amino:** This indicates that an amino group (NH2) is attached to the isoquinoline ring at position 1.
* **5-(4-morpholinyl):** This means a morpholine ring (containing a nitrogen and an oxygen) is attached to the isoquinoline ring at position 5.
* **2-carboxylic acid ethyl ester:** This refers to an ethyl ester group (-COOC2H5) attached to the carbon at position 2 on the isoquinoline ring.

**Potential Research Importance:**

The detailed information about this specific compound's research importance is not readily available in general resources. However, we can make some educated guesses based on its structural features:

* **Potential Biological Activity:**
* **Heterocyclic Structure:** The thieno[2,3-c]isoquinoline core, along with the morpholine ring, is known to appear in molecules with potential biological activity. This structure is often found in compounds with drug-like properties.
* **Amino Group:** The amino group can potentially interact with biological targets, potentially influencing enzyme activity or receptor binding.
* **Carboxylic Acid Ethyl Ester:** The ester group can be a site for chemical modification, allowing for the development of analogues with different properties.

* **Drug Discovery:** The compound could be a potential lead compound for drug discovery. Its structure suggests it could exhibit biological activity against certain diseases or conditions.

**To find out more about this specific compound's research importance, you would need to:**

1. **Search Scientific Databases:** Use databases like PubMed, Scopus, Web of Science, or Google Scholar with specific keywords like thieno[2,3-c]isoquinoline, morpholine, amino, carboxylic acid ethyl ester, and the specific compound name.
2. **Consult Chemical Databases:** Databases like ChemSpider or PubChem might have information on this compound's synthesis, properties, and potential biological activity.
3. **Look for Published Research:** Look for research papers or patents mentioning this specific compound or related compounds.

Remember, without specific information about the compound's synthesis, biological testing, or applications, it's hard to say definitively why it would be important.

Cross-References

ID SourceID
PubMed CID658121
CHEMBL ID1336329
CHEBI ID108450

Synonyms (18)

Synonym
ethyl 1-amino-5-morpholin-4-yl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylate
smr000034349
MLS000038157
OPREA1_209160
OPREA1_729633
ethyl 1-amino-5-(morpholin-4-yl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylate
STK093843
CHEBI:108450
MLS002581674
AKOS000279732
CCG-18838
HMS2337K18
CHEMBL1336329
Q27187298
1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylic acid ethyl ester
SR-01000470378-1
sr-01000470378
ethyl 1-amino-5-(morpholin-4-yl)-6h,7h,8h,9h-thieno[2,3-c]isoquinoline-2-carboxylate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
thienopyridineAny organic heterobicyclic compound whose skeleton results from the formal ortho-fusion of any bond of a pyridine with any bond of a thiophene.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (12)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, HADH2 proteinHomo sapiens (human)Potency3.16230.025120.237639.8107AID886; AID893
Chain B, HADH2 proteinHomo sapiens (human)Potency3.16230.025120.237639.8107AID886; AID893
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency31.62280.177814.390939.8107AID2147
acid sphingomyelinaseHomo sapiens (human)Potency7.943314.125424.061339.8107AID504937
thioredoxin reductaseRattus norvegicus (Norway rat)Potency22.53580.100020.879379.4328AID588453; AID588456
ClpPBacillus subtilisPotency31.62281.995322.673039.8107AID651965
GLS proteinHomo sapiens (human)Potency3.98110.35487.935539.8107AID624170
TDP1 proteinHomo sapiens (human)Potency12.99530.000811.382244.6684AID686979
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.62280.011212.4002100.0000AID1030
67.9K proteinVaccinia virusPotency14.12540.00018.4406100.0000AID720580
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency31.62280.001815.663839.8107AID894
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]